Genomic Instability and Bystander Effects: A Paradigm Shift in Radiation Biology?
نویسندگان
چکیده
منابع مشابه
Bystander effects in radiation-induced genomic instability.
Exposure of GM10115 hamster-human hybrid cells to X-rays can result in the induction of chromosomal instability in the progeny of surviving cells. This instability manifests as the dynamic production of novel sub-populations of cells with unique cytogenetic rearrangements involving the "marker" human chromosome. We have used the comet assay to investigate whether there was an elevated level of ...
متن کاملVanguards of paradigm shift in radiation biology: radiation-induced adaptive and bystander responses.
The risks of exposure to low dose ionizing radiation (below 100 mSv) are estimated by extrapolating from data obtained after exposure to high dose radiation, using a linear no-threshold model (LNT model). However, the validity of using this dose-response model is controversial because evidence accumulated over the past decade has indicated that living organisms, including humans, respond differ...
متن کاملRadiation-induced genomic instability and bystander effects: implications for radiation protection\*
Evidence has emerged over the past decade for the existence of two cellular phenomenons which challenge the standard paradigms for the induction of biological effects by ionizing radiation. In bnth cases, important genetic changes arke in cells that in themselves receive no radiation exposure. In the first, radiation induces a type of transmissible genomic instability in cells that leads to a p...
متن کاملGenomic Instability and Bystander Effect – Implications for Radiation Protection
The main results of the EC project ‘Genomic instability and radiation-induced cancer’ (RADINSTAB) are reviewed and the potential implications of genomic instability and bystander effect for risk assessment and radiation protection discussed. A basic paradigm in radiobiology is that, after exposure to ionising radiation, the deposition of energy in the cell nucleus and the resulting damage to DN...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Military Medicine
سال: 2002
ISSN: 0026-4075,1930-613X
DOI: 10.1093/milmed/167.suppl_1.44